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Acetamidomalonic acid diethyl ester → Diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetamidomalonic acid diethyl ester | HCID 14041 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | 2H-Pyran, 2-[(12-bromododecyl)oxy]tetrahydro- | HCID 11078592 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate | HCID 21849423 | 39.2% |
反応手順
Diethyl acetamidomalonate (6.996 g) and 3.189 g of sodium ethoxide were dissolved in 130 ml of dry ethanol and a solution of 10.698 g of 1-bromo-12-tetrahydropyranyloxydodecane in 200 ml of dry ethanol was added thereto. The mixture was refluxed under heating for 8 hours. The solvent was distilled away under reduced pressure and the residue was purified by silica gel column chromatography to give 5.837 g of diethyl 2-acetamido-2-(12-tetrahydropyranyloxydodecyl)malonate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05719176 |
| 出典データセット | uspto-grants-1998_02 |
| ORD ID | ord-b9e03d9ea2a4433f88a7091e3e09ef8d |
| 出典メモ | uspto-grants-1998_02 |