2-Amino-2-(1,2-dihydroxy-4-octadecenyl)-1,3-propanediol → 2-Amino-2-(1,2-dihydroxyoctadecyl)-1,3-propanediol

HRID 862850Notes

Reaction equation

HRID 862850 reaction equation
[NH2:1][C:2]([CH:7]([OH:26])[CH:8]([OH:25])[CH2:9][CH:10]=[CH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])([CH2:5][OH:6])[CH2:3][OH:4]>CO.[C].[Pd]>[NH2:1][C:2]([CH:7]([OH:26])[CH:8]([OH:25])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])([CH2:3][OH:4])[CH2:5][OH:6]

Participants

4

Reactant 1

HCID 538638012-Amino-2-(1,2-dihydroxy-4-octadecenyl)-1,3-propanediol

Product 1

HCID 218493532-Amino-2-(1,2-dihydroxyoctadecyl)-1,3-propanediolYield 50.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

2-Amino-2-(1,2-dihydroxy-4-octadecenyl)-1,3-propanediol (68.0 mg) was dissolved in 14 ml of methanol and 6.8 mg of 5% palladium-carbon was added thereto. The catalytic reduction was conducted at ordinary temperature and at atmospheric pressure day and night. After the reaction, the catalyst was filtered off and the filtrate was concentrated under reduced pressure to give 34.3 mg of the subject compound.

Workup

  1. customAfter the reaction
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-94582ee474eb43a884fdfb9e77a27994
Source dataset
uspto-grants-1998_02
Patent number
US05719176

Reaction notes

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