Hydrochloric Acid → Ampicillin Trihydrate

Participants

Reaction Steps

The resultant crude protected ampicillin mixture is worked up by treating with a mixture of ice-water and concentrated HCl. After phase separation the aqueous phase is brought to pH 4.5. The title compound is obtained after filtration and washing with 90% aqueous acetone, followed by drying. Yield 66.34 g=89%. Purity 98.8%.

Provenance & Evidence