Hydrochloric Acid → 1-methyl-3-propyl-1H-pyrazole-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

1-Methyl-3-n-propylpyrazole-5-carboxylic acid ethyl ester (20.2 g, 0.10 mol) was suspended in 6N aqueous sodium hydroxide solution (50 ml, 0.30 mol). The mixture was heated to 80° C. for 2 hours then diluted with water (50 ml) and acidified with concentrated hydrochloric acid (25 ml). Filtration gave the carboxylic acid as pale brown crystals (12.3 g, 71%), m.p. 150°-154° C. Found: C,56.99; H,7.25; N,16.90. C8H12N2O2 requires C,57.13; H, 7.19; N,16.66%.

Provenance & Evidence