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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 862912Generated: October 30, 2026

ethyl (RS)-I-(4methoxyphenyl)-3-phenylindene-2-carboxylate → Ethyl(1RS,2SR,3SR)-1-(4-Methoxyphenyl)-3-phenylindane-2-carboxylate

https://huagongshe.com/reaction/862912

Reaction equation

Participants

RoleNameHCIDCharge
Reactantethyl (RS)-I-(4methoxyphenyl)-3-phenylindene-2-carboxylateHCID 18969659—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
ProductEthyl(1RS,2SR,3SR)-1-(4-Methoxyphenyl)-3-phenylindane-2-carboxylateHCID 67643697—

Reaction Steps

To a solution of ethyl(RS)-1-(4-methoxyphenyl)-3-phenylindene-2-carboxylate (5.75 g, 15 mmol) in EtOAc (150 ml) was added 5% palladium on activated carbon (600 mg). The resulting suspension was stirred under an atmosphere of H2 for 1 d, then was filtered through a pad of Celite. The filtrate was concentrated under reduced pressure to afford the title compound, which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05719182
Source datasetuspto-grants-1998_02
ORD IDord-1f4b90e1e2d94533801c39a9dc26cb53
Source noteuspto-grants-1998_02