Hydrazine → HCID 19699129, compound

HRID 863022Notes

Reaction equation

HRID 863022 reaction equation
C[N:2]([CH:4]=[C:5]1[CH2:11][CH2:10][N:9]([C:12](=[O:23])[C:13]2[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][C:14]=2[Cl:22])[C:8]2[CH:24]=[CH:25][S:26][C:7]=2[CH2:6]1)C.[NH2:27]N>C(O)C>[Cl:22][C:14]1[CH:15]=[C:16]([N+:19]([O-:21])=[O:20])[CH:17]=[CH:18][C:13]=1[C:12]([N:9]1[CH2:10][CH2:11][C:5]2[CH:4]=[N:2][NH:27][C:6]=2[C:7]2[S:26][CH:25]=[CH:24][C:8]1=2)=[O:23]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 54502621HCID 54502621, compound

Product 1

HCID 19699129HCID 19699129, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture of 2.2 g of 7-[(dimethyl-amino)methylene]-4,5,6,7-tetrahydro-4-(2-chloro-4-nitrobenzoyl)-8H-thieno[3,2-b]azepine in 40 ml of ethanol is added 341 μl of hydrazine followed by heating at 60° C. for 1.5 hours. The volatiles are evaporated in vacuo to a residue which is dissolved in 100 ml of ethyl acetate and filtered through a pad of hydrous magnesium silicate. The filtrate is evaporated in vacuo to give 1.85 g of the desired product as a yellow-orange solid.

Workup

  1. customThe volatiles are evaporated in vacuo to a residue which
  2. dissolutionis dissolved in 100 ml of ethyl acetate
  3. filtrationfiltered through a pad of hydrous magnesium silicate
  4. customThe filtrate is evaporated in vacuo

Sources & evidence

ORD record
ord-baac543988d3410daca6dc1f0398bc66
Source dataset
uspto-grants-1998_02
Patent number
US05719278

Reaction notes

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