Hexane → 4-[([1,1′-Biphenyl]-2-ylcarbonyl)amino]-3-methoxybenzoyl chloride

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Reaction Steps

A solution of 2.69 g of 4-[([1,1'-biphenyl]-2-carbonyl]amino]-3-methoxy benzoic acid in 5 ml of thionyl chloride is heated on a steam bath for 1 hour under Argon. The volatiles are removed in vacuo to give a residue which is stirred with hexane to give 2.58 g of crystalline solid, m.p. 121°-123° C. M+ =361.

Provenance & Evidence