HCID 19699620, compound → HCID 19699291, compound

HRID 863056Notes

Reaction equation

HRID 863056 reaction equation
[O:1]1[CH:3]2[CH2:4][C:5]3[C:10]([CH:2]12)=[CH:9][C:8]([F:11])=[C:7]([F:12])[CH:6]=3>C(O)C.[Pd]>[F:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][C:7]=1[F:12])[CH2:4][CH:3]([OH:1])[CH2:2]2

Participants

4

Reactant 1

HCID 19699620HCID 19699620, compound

Product 1

HCID 19699291HCID 19699291, compoundYield 59.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Impure 1,2-epoxy-5,6-difluoroindane (4.5 g) was dissolved in 100 mL of ethanol and hydrogenated over 10% palladium on carbon (450 mg) for 15 hours. The mixture was filtered and evaporation gave 5,6-difluoro-2-hydroxyindane (2.72 g, 15.9 mmol), m.p. 57°-58° C.

Workup

  1. filtrationThe mixture was filtered
  2. customevaporation

Sources & evidence

ORD record
ord-ce8f9ee6a61d4c36b841e2522a1afeb9
Source dataset
uspto-grants-1998_02
Patent number
US05719280

Reaction notes

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