HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)vinyl]phenyl}acrylate → Ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)ethyl]phenyl}propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)vinyl]phenyl}acrylate | HCID 53722136 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)ethyl]phenyl}propionate | HCID 19699411 | 121.7% |
Reaction Steps
Ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)vinyl]phenyl}acrylate (5.7 g, 18.4 mmol) in 250 mL of ethyl acetate was hydrogenated at 60 psi over 10% palladium on carbon (0.57 g) for 4 hours and then the mixture was filtered through Celite. Evaporation of the solvent gave ethyl 3-{3,5-difluoro-2-[2-(ethoxycarbonyl)ethyl]phenyl}propionate (5.73 g, 22.4 mmol) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719280 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-98a402fe569f4c5eb6bc2e0ac3e25fd9 |
| Source note | uspto-grants-1998_02 |