Hydrochloric Acid → Nepicastat hydrochloride anhydrous

Participants

Reaction Steps

The (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione was dissolved in methanol and treated with 1.5 equivalents of anhydrous hydrogen chloride in ethyl ether. Removal of the solvents by co-evaporation with ethyl acetate gave (S)-5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1,3-dihydroimidazole-2-thione hydrochloride, m.p. 245° C., [aα]D25 =11.30° (c=0.5, DMSO).

Provenance & Evidence