HCID 10316940, compound → HCID 10155767, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (1RS,2SR)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)-3-oxo-indane-2-carboxylate (26.2 g, 71 mmol) was dissolved in toluene (250 mL) and DDQ (dichlorodicyano-quinone) (16.5 g, 71 mmol) was added. The mixture was heated at 80° C. for 2 h. then cooled, filtered and the solvent removed in vacuo. The product was purified by flash column chromatography on silica gel (eluant: EtOAc/hexane, 20:80) to give the title compound as an orange solid (11.3 g, 44%); m.p. 125°-126° C. Anal. Calc. for C21H18O6 : C, 68.85; H, 4.95. Found: C, 68.45; H, 4.97.

Provenance & Evidence