Hydrochloric Acid → HCID 131720504, compound

Participants

Reaction Steps

To 0.5 mL CH2Cl2 was added 48.6 mg (200 μmole) of EtOCO-Cha, 34.8 μL (200 μmole) DIEA, and 88.4 mg (200 μmole) BOP. After 3 min, 19.4 mg (200 μmole) N,O-dimethyl-hydroxylamine.HCl and 34.8 μL (200 μmole) DIEA were added. The reaction was monitored by TLC, and after 90 min it was diluted with CH2Cl2, washed 2× with dilute HCl and 2× with saturated NaHCO3. The organic layer was dried with Na2SO4, filtered, and the filtrate evaporated by rotary evaporation to give the title compound. NMR (300 MHz, CDCl3): a 4.72 (br m, Cha-α, 1H), 4.04 (q, CH3CH2OCO, 2H), 3.72 (s, N(CH3)OCH3, 3H), 3.13 (s, N(CH3)OCH3, 3H), 1.17 (t, CH3CH2OCO, 3H).

Provenance & Evidence