HCID 14649483, compound → HCID 19699945, compound

HRID 863200Notes

Reaction equation

HRID 863200 reaction equation
[CH2:1]([O:3][C:4]([CH:6]([P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])[CH2:7][CH2:8][CH2:9][O:10]C1CCCCO1)=[O:5])[CH3:2]>CO>[CH2:1]([O:3][C:4]([CH:6]([P:17](=[O:24])([O:18][CH2:19][CH3:20])[O:21][CH2:22][CH3:23])[CH2:7][CH2:8][CH2:9][OH:10])=[O:5])[CH3:2]

Participants

3

Reactant 1

HCID 14649483HCID 14649483, compound

Product 1

HCID 19699945HCID 19699945, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The diethyl 1-ethoxycarbonyl-4-(tetrahydropyran-2-yloxy)butylphosphonate prepared in the step (a) was dissolved in 500 ml of methanol, followed by the addition of 20 g of a cation-exchange resin (Dowex 50w-8, H type). The obtained mixture was mildly refluxed for 7 hours, cooled to room temperature, and filtered to remove the resin. The filtrate was distilled to remove the solvent, giving 68.8 g of the title compound.

Workup

  1. temperatureThe obtained mixture was mildly refluxed for 7 hours
  2. filtrationfiltered
  3. customto remove the resin
  4. distillationThe filtrate was distilled
  5. customto remove the solvent

Sources & evidence

ORD record
ord-f67dd01502b64d07a98b27b4673f14d2
Source dataset
uspto-grants-1998_02
Patent number
US05719303

Reaction notes

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