HCID 131720508, compound → HCID 131720507, compound

Participants

Reaction Conditions

Reaction Steps

28 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(R),7,7-trimethyl-8-[3(R,S)-tert-butoxycarbonyl-1,2,3,4-tetrahydroquinolin-1-ylcarbonyl]-octanoic acid (N-butyl)amide are dissolved in 2 ml of 4N hydrochloric acid in dioxane and the solution is stirred at 20° C. for 30 min. The reaction mixture is diluted with dioxane and lyophilized. The crude product is purified by means of FC (5 g of silica gel, mobile phases N and O). This gives the title compound as a diastereomer mixture: Rf (O)=0.32; Rt (I)=23.8 min; FAB-MS: (M+H)+ =532.

Provenance & Evidence