Butylamine → 3(R,S)-butylaminocarbonyl-1,2,3,4-tetrahydroquinoline

Participants

Role	Name	HCID	Charge
Reactant	Butylamine	HCID 8007	—
Reactant	Methyl 1,2,3,4-tetrahydro-3-quinolinecarboxylate	HCID 283526	—
Product	3(R,S)-butylaminocarbonyl-1,2,3,4-tetrahydroquinoline	HCID 19697883	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

A mixture of 500 mg of 3(R,S)-methoxycarbonyl-1,2,3,4-tetrahydroquinoline (Example 1r) and 1 ml of n-butylamine is stirred at 60° C. for 1 h. Purification of the crude product by means of FC over 50 g of silica gel (mobile phase Z) gives 3(R,S)-butylaminocarbonyl-1,2,3,4-tetrahydroquinoline: Rf (Z)=0.21.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05719141
Source dataset	uspto-grants-1998_02
ORD ID	ord-a3f062c980fa403cad2cdac12411e63c
Source note	uspto-grants-1998_02