Methylamine → HCID 131720509, compound

Participants

Reaction Steps

92 mg of 5(S)-Amino-4(S)-hydroxy-2(R),7,7-trimethyl-8-[2(R,S)-methoxycarbonyl-3,4-dihydro-2H-1,4-benzothiazin-4-ylcarbonyl]-octanoic acid (N-butyl)amide (Example 18)) are dissolved in 3 ml of a 5N methylamine solution in dimethylformamide and the solution is left to stand at room temperature for 26 h. After purification of the concentrated crude product by means of FC (mobile phase T) over 50 g of silica gel, the title compound is obtained as a diastereomer mixture: Rf (T)=0.26/0.31; FAB-MS: (M+H)+ =507.

Provenance & Evidence