Ethyl 3,4-dihydro-2H-1,4-benzoxazine-2-carboxylate → HCID 67625576, compound

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Reaction Steps

1.0 g of 2(R,S)-ethoxycarbonyl-3,4-dihydro-2H-1,4-benzoxazine and 1.2 g of glycine-tert-butyl ester are heated at 80° C. in 10 ml of toluene. After 5 h, the mixture is evaporated and pure 2(R,S)-(tert-butoxycarbonylmethylaminocarbonyl)-3,4-dihydro-2H-1,4-benzoxazine is isolated by means of FC over 100 g of silica gel (mobile phase Z): Rf (Z)=0.38.

Provenance & Evidence