N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine → N-Benzyloxycarbonyl-3(R,S)-isopropoxycarbonyl-1,2,3,4-tetrahydroquinoline

Participants

Role	Name	HCID	Charge
Reactant	N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine	HCID 87682	—
Reactant	1-[(Benzyloxy)carbonyl]-1,2,3,4-tetrahydroquinoline-3-carboxylic acid	HCID 19697589	—
Reactant	5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(R),7,7-trimethyl-8-[3(R,S)-ethoxycarbonyl-1,2,3,4-tetrahydroquinolin-1-ylcarbonyl]-octanoic acid (N-butyl)amide	HCID 131720511	—
Product	N-Benzyloxycarbonyl-3(R,S)-isopropoxycarbonyl-1,2,3,4-tetrahydroquinoline	HCID 19697655	—

Reaction Steps

The title compound is prepared analogously to Example 1s) starting from 1.87 g of N-benzyloxycarbonyl-1,2,3,4-tetrahydroquinoline-3(R,S)-carboxylic acid and 5.1 ml of N,N-dimethylformamide diisopropyl acetal Rf (A)=0.78; MS: (M)+ =353.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05719141
Source dataset	uspto-grants-1998_02
ORD ID	ord-aeb6b980b9d34ae49539c4e6195f936e
Source note	uspto-grants-1998_02