Magnesium → 10-Benzyloxy-6(S)-tert-butoxycarbonylamino-5(S)-hydroxy-3(R,S)-isopropyl-8,8-dimethyldec-1-ene

Participants

Reaction Steps

88.5 g of 1-bromo-2(R,S)-isopropyl-3-butene, 13 g of magnesium powder and 41.9 g of 6-benzyloxy-2(S)-tert-butoxycarbonylamino-4,4-dimethyl-hexanal are reacted in a manner analogous to that described in Example 37f). Purification is carried out by FC over 1 kg of silica gel (mobile phases G and E): Rf (3:1 mixture of toluene and ethyl acetate)=0.47; Rt (I)=33.8/34.2 min; FAB-MS: (M+H)+ =520.

Provenance & Evidence