4-Nitrophenyl formate → HCID 131720513, compound

Participants

Reaction Steps

195 mg of 5(S)-amino-4(S)-hydroxy-2(R),7,7-trimethyl-8-[2(R,S)-methoxycarbonyl-3,4-dihydro-2H-1,4-benzothiazin-4-ylcarbonyl]-octanoic acid (N-butyl)amide (Example 18)) are reacted with 128 mg of 4-nitrophenyl formate in a manner analogous to that described in Example 17) and the product is purified over 30 g of silica gel (mobile phase M). The title compound is obtained as a yellowish-coloured solid: Rf (N)=0.20; FAB-MS: (M+H)+ =536.

Provenance & Evidence