HCID 15727118, compound → HCID 19697594, compound

Participants

Reaction Steps

A solution of 6.5 g of 3-methylsulfonylquinoline in 200 ml of glacial acetic acid is hydrogenated in the presence of 690 mg of platinum oxide at 50° C. for 13 h. After the reaction mixture has been filtered over Celite® 545, the filtrate is concentrated and the crude product is purified by means of FC over 200 g of silica gel with a 99:1 mixture of methylene chloride and methanol as the mobile phase: Rf (K)=0.45; anal. calc. for C10H13NO2S: C56.85%, H6.20%, N6.63%; found C56.95%, H6.17%, N6.77%.

Provenance & Evidence