2-(2-Nitrophenoxy)acetamide → HCID 20283931, compound

Participants

Reaction Steps

2.0 g of 2-(carbamoylmethoxy)nitrobenzene are hydrogenated in the presence of 100 mg of palladium-on-charcoal (10% of Pd) in 50 ml of tetrahydrofuran at room temperature under normal pressure for 2 h. The reaction mixture is filtered over Hyflo® and concentrated. 2-(Carbamoylmethoxy)aniline is obtained as white crystals: mp 117° C.; Rf (O)=0.36; FAB-MS: (M+H)+ =167; anal. calc. for C8H10N2O2 : C57.82%, H6.07%, N16.86%; found C57.71%, H6.04%, N16.87%.

Provenance & Evidence