HCID 12378950, compound → HCID 19697797, compound

HRID 863258Notes

Reaction equation

HRID 863258 reaction equation
[CH2:1]([S:3]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)(=[O:5])=[O:4])[CH3:2]>C(O)(=O)C.[Pt]=O>[CH2:1]([S:3]([CH:6]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH2:7]1)(=[O:4])=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 12378950HCID 12378950, compound

Product 1

HCID 19697797HCID 19697797, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

A solution of 0.3 g of 3-ethylsulfonylquinoline in 15 ml of glacial acetic acid is hydrogenated in the presence of 30 mg of platinum oxide at 50° C. for 22 h. After working up analogously to Example 52c) and FC over 30 g of silica gel (mobile phase I), the pure title compound is obtained: mp 88°-90° C., Rf (K)=0.51; IR(KBr): 3380(s), 1590, 1500(m), 1270(s), 1130(s), 750(s); anal. calc. for C11H15NO2S: C58.64%, H6.71%, N6.22%; found C58.95,6.75, N6.21.

Sources & evidence

ORD record
ord-c1f12575f68b48388da2868090adf25c
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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