Methyl iodide → methyl quinoline-2-carboxylate

Participants

Reaction Steps

Reaction of 10.0 g of quinaldic acid with 5.4 ml of methyliodide by the method described in Example 97f) for 20 h at room temperature and purification of the crude product by FC over 80 g of silica gel (mobile phase C) gives methyl quinaldate as a white solid: Rf (50:50:6 mixture of hexane, ethyl acetate and glacial acetic acid)=0.65.

Provenance & Evidence