Tetrabutylammonium Fluoride → HCID 86752100, compound

Participants

Reaction Steps

475 mg of 3-[N-tert-butoxycarbonyl-4(S)-[4-triisopropylsilyloxy-2(S)-methylbutyl]-2,2-dimethyl-1,3-oxazolidin-5(S)-yl]-2(R)-methyl-propionic acid (N-butyl)amide, dissolved in 12 ml of tetrahydrofuran, are stirred together with 1.63 ml of a 1M tetrabutylammonium fluoride solution in tetrahydrofuran at room temperature for 3 h. The organic phase is washed with saturated sodium chloride solution, added over sodium sulfate and concentrated. The crude product is purified by FC over 50 g of silica gel (mobile phase H). The title compound is obtained as the pure diastereomer: Rf (H)=0.48.

Provenance & Evidence