HRID863270

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CCOCc1ccccc1)C[C@H](NC(=O)OC(C)(C)C)[C@@H]1C[C@@H](Cc2ccccc2)C(=O)O1

HCID67625456

未命名化合物

PRODUCTS

生成物

结构：CCCCNC(=O)[C@H](Cc1ccccc1)C[C@H](O)[C@H](CC(C)(C)CCOCc1ccccc1)NC(=O)OC(C)(C)C

HCID86752103

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8007

Butylamine

C4H11N

PROCEDURE

实验过程

A solution of 502 mg of 3(R)-benzyl-5(S)-[5-benzyloxy-1 (S)-tert-butoxycarbonylamino-3,3-dimethyl-pentyl]-2-oxo-tetrahydrofuran in 8.5 ml of butylamine is stirred at room temperature for 20 h and concentrated and the residue is purified by chromatography over silica gel (mobile phase A): Rf (A)=0.47; FAB-MS: (M+H)+ =569.

WORKUP

后处理

concentrationconcentrated
customthe residue is purified by chromatography over silica gel (mobile phase A)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1056d6f3352f4f399fa81d600552f34d
来源数据集: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05719141
来源说明: uspto-grants-1998_02

反应 SMILES

[CH2:1]([C@@H:8]1[CH2:12][C@@H:11]([C@@H:13]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:14][C:15]([CH3:27])([CH3:26])[CH2:16][CH2:17][O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:10][C:9]1=[O:36])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(N)CCC>[CH2:13]([NH:28][C:9](=[O:36])[C@H:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:12][C@H:11]([OH:10])[C@@H:13]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:33])[CH3:34])=[O:30])[CH2:14][C:15]([CH3:26])([CH3:27])[CH2:16][CH2:17][O:18][CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[CH2:11][CH2:12][CH3:8]