HCID 19697802, compound → HCID 131720521, compound

HRID 863277Notes

Reaction equation

HRID 863277 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[NH:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[O:7][CH2:6]1)=[O:4].[CH2:15]([NH:19][C:20](=[O:56])[C@H:21]([CH3:55])[CH2:22][C@H:23]([OH:54])[C@@H:24]([NH:46]C(OC(C)(C)C)=O)[CH2:25][C:26]([CH3:45])([CH3:44])[CH2:27][C:28](N1C2C(=CC=CC=2)CC(NC(C)=O)C1)=[O:29])[CH2:16][CH2:17][CH3:18]>>[CH2:15]([NH:19][C:20](=[O:56])[C@H:21]([CH3:55])[CH2:22][C@H:23]([OH:54])[C@@H:24]([NH2:46])[CH2:25][C:26]([CH3:44])([CH3:45])[CH2:27][C:28]([N:10]1[C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[O:7][CH2:6][CH:5]1[C:3]([O:2][CH3:1])=[O:4])=[O:29])[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 19697802HCID 19697802, compoundHCID 131720517HCID 131720517, compound

Product 1

HCID 131720521HCID 131720521, compound

Procedure

Starting from 78 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(R),7,7-trimethyl-8-3(R,S)-methoxycarbonyl-3,4-dihydro-2H-1,4-benzoxazin-4-ylcarbonyl]-octanoic acid (N-butyl)amide (Example 80)) in a manner analogous to that described in Example 1): Rf (S)=0.37; FAB-MS: (M+H)+ =492.

Sources & evidence

ORD record
ord-27b60fa8de644dfc9e9d5d8cadcc2c09
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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