HCID 54555357, compound → HCID 86752105, compound

HRID 863278Notes

Reaction equation

[CH2:1]([NH:5][C:6](=[O:37])[C@H:7]([CH3:36])[CH2:8][C@H:9]([OH:35])[C@@H:10]([NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH2:11][C@@H:12]([CH3:26])[CH2:13][CH2:14][O:15][Si:16]([CH:23]([CH3:25])[CH3:24])([CH:20]([CH3:22])[CH3:21])[CH:17]([CH3:19])[CH3:18])[CH2:2][CH2:3][CH3:4].[CH2:38](NC(=O)[C@H](C)C[C@H](O)[C@@H](NC(OC(C)(C)C)=O)CC(C)(C)CC(N1C2C(=CC=CC=2)CC(S(CC)(=O)=O)C1)=O)[CH2:39][CH2:40]C>>[CH2:1]([NH:5][C:6](=[O:37])[C@H:7]([CH3:36])[CH2:8][C@@H:9]1[O:35][C:39]([CH3:40])([CH3:38])[N:27]([C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[C@H:10]1[CH2:11][C@@H:12]([CH3:26])[CH2:13][CH2:14][O:15][Si:16]([CH:17]([CH3:19])[CH3:18])([CH:20]([CH3:21])[CH3:22])[CH:23]([CH3:24])[CH3:25])[CH2:2][CH2:3][CH3:4]

Participants

Reactant 2

HCID 54555357HCID 54555357, compound

HCID 131720522HCID 131720522, compound

Product 1

HCID 86752105HCID 86752105, compound

Procedure

The title compound is prepared in a manner analogous to that described in Example 72e) starting from 800 mg of 5(S)tert-butoxycarbonylamino-4(S)-hydroxy-9-triisopropylsilyloxy-2(R),7(R)-dimethyl-nonanoic acid (N-butyl)amide: Rf (A)=0.69.

Sources & evidence

ORD record: ord-92511295441d401ca9a362e6a485ebf0
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05719141

Reaction notes

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