(4S)-Dihydro-4-methyl-2(3H)-furanone → HCID 54557762, compound

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Reaction Steps

In a manner analogous to that described in Example 72g), the title compound is obtained starting from 3.2 g of 2(S)-tert-butoxycarbonylamino-4(R)-methyl-6-triisopropylsilyloxyhexanal (Rf (D)=0.36), which is prepared by processes analogous to those described in Examples 72h to 72n), starting from (S)-3-methylbutyrolactone, and is purified by FC over 400 g of silica gel (mobile phase gradient from E to B), the two stereoisomers being separated. This gives the title compound (diastereomer I): Rf (A)=0.58; and diastereomer II: Rf (A)=0.47.

Provenance & Evidence