HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → HCID 19697861, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | HCID 19697557 | HCID 19697557 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 19697861 | HCID 19697861 | — |
Reaction Steps
The title compound is prepared analogously to Example 87b) starting from 3.0 g of N-benzyloxycarbonyl-2(R,S)-hydroxymethyl-3,4-dihydro-2H-1,4-benzoxazine, 2.4 g of sodium bis(trimethylsilyl)amide and 0.94 ml of methyliodide: Rf (3:1 mixture of toluene and ethyl acetate)=0.56; Rt (I)=27.9 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719141 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-f5c788d3ee744dceb834d34e59bfc03e |
| Source note | uspto-grants-1998_02 |