Hydrochloric Acid → HCID 131720523, compound

Participants

Reaction Steps

2 ml of 4N hydrochloric acid in dioxane are added to 116 mg of 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-6-[1-[3(R,S)-methylaminocarbonyl-1,2,3,4-tetrahydroquinolin-1-ylcarbonylmethyl]cyclopropyl]-2(R)-methyl-hexanoic acid (N-butyl)amide at 0° C. and the mixture is stirred for 2 h. 2 ml of toluene are added and the reaction mixture is concentrated. The oily residue is chromatographed over 10 g of silica gel (mobile phases K and L). This gives the title compound as a diastereomer mixture: Rf (P)=0.11; Rt (IV)=32.6 min; FAB-MS: (M+H)+ =487.

Provenance & Evidence