2,2-Dimethoxypropane → HCID 86752106, compound

Participants

Reaction Steps

The 5(S)-tert-butoxycarbonylamino-6-[1-(2-benzyloxyethyl)cyclopropyl]-4(S)-hydroxy-2(R)-methyl-hexanoic acid (N-butyl)amide thus obtained is reacted with dimethoxypropane and p-toluenesulfonic acid hydrate in a manner analogous to that described in Example 1 d) and the product is purified by means of FC over 80 g of silica gel (mobile phase C). This gives the title compound as the pure diastereomer: Rf (A)=0.58,

Provenance & Evidence