HCID 22882481, compound → HCID 22882483, compound

Participants

Reaction Steps

27.05 g of sodium-hexamethyldisilazane are added in portions to a suspension of 52.7 g of methyltriphenylphosphonium bromide in 470 ml of tetrahydrofuran in the course of 10 min. 20.9 g of 3-tert-butoxycarbonyl-2,2-dimethyl-4(S)-[(1-formylcyclopropyl)methyl]-1,3-oxazolidine are added dropwise to this mixture at 5° C. in the course of 10 min, and after warming to room temperature, the mixture is stirred for 1 h. The mixture is poured onto ice-water and the aqueous phase is extracted with methylene chloride. The title compound is purified by means of FC over 900 g of silica gel (mobile phase G): Rf (G)=0.56.

Provenance & Evidence