Dimethylcarbamoyl Chloride → HCID 22377310, compound

Participants

Reaction Steps

2.0 g of 3-aminoquinoline are added in portions to a solution of 1.65 ml of N,N-dimethylcarbamoyl chloride in 3.9 ml of pyridine and the reaction mixture is stirred at room temperature for 24 h. The reaction mixture is then poured onto 50 ml of ice-water. Customary working up and purification of the crude product by chromatography over 100 g of silica gel (mobile phase L) gives 3-(N,N-dimethylaminocarbonylamino)quinoline: Rf (L)=0.23; MS:M+=215.

Provenance & Evidence