HCID 13078459, compound → HCID 19697653, compound

HRID 863300Notes

Reaction equation

HRID 863300 reaction equation
[CH3:1][NH:2][C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:4]>C(O)C>[CH3:1][NH:2][C:3]([NH:5][CH:6]1[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH2:7]1)=[O:4]

Participants

3

Reactant 1

HCID 13078459HCID 13078459, compound

Product 1

HCID 19697653HCID 19697653, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.4 g of 3-(methylaminocarbonylamino)quinoline in 40 ml of ethanol are hydrogenated in a manner analogous to that described in Example 93). The crude product is purified over 200 g of silica gel with a 99:1:1 mixture of methylene chloride, methanol and glacial acetic acid as the mobile phase: Rf (L)=0.34; MS: M+ =205.

Workup

  1. customThe crude product is purified over 200 g of silica gel with a 99:1:1 mixture of methylene chloride, methanol and glacial acetic acid as the mobile phase

Sources & evidence

ORD record
ord-2f3968146a9446528bd3ec4f00bcdeba
Source dataset
uspto-grants-1998_02
Patent number
US05719141

Reaction notes

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