3-Aminoquinoline → HCID 13078459, compound

Participants

Reaction Steps

0.99 ml of methyl isocyanate is added to a solution of 2.0 g of 3-aminoquinoline in 15 ml of methylene chloride under argon and the mixture is heated under reflux for 2 h. A further 0.95 ml of methyl isocyanate is added and the reaction mixture is refluxed again for 2 h. The crude product is chromatographed over 100 g of silica gel (mobile phase gradient from L to P). This gives the title compound as a crystalline solid: Rf (L)=0.2; M+=201.

Provenance & Evidence