HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminoquinoline → 1,2,3,4-Tetrahydroquinolin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminoquinoline | HCID 11375 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,2,3,4-Tetrahydroquinolin-3-amine | HCID 4055118 | — |
Reaction Steps
The solution of 35 g of 3-aminoquinoline in 330 ml of ethanol is hydrogenated in the presence of a total of 27 g of Raney nickel at 55° C. under a pressure of 90 bar for 44 h. After customary working up, the crude product is purified over 900 g of silica gel (mobile phase S): Rf (S)=0.40; MS: M+ =148.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719141 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-65d9b0708ad842888cece32cbef70280 |
| Source note | uspto-grants-1998_02 |