HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 863315Generated: October 30, 2026
Sodium Hydroxide → 1-((tert-butoxy)carbonyl)-2,3-dihydro-1H-indole-3-carboxylic acid
https://huagongshe.com/reaction/863315
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-tert-Butyl 3-ethyl indoline-1,3-dicarboxylate | HCID 19697784 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | 1-((tert-butoxy)carbonyl)-2,3-dihydro-1H-indole-3-carboxylic acid | HCID 19697750 | — |
Reaction Steps
A mixture of 0.7 g of ethyl 1-(tert-butoxycarbonyl)indoline-3(R,S)-carboxylate (Example 97d) in 18 ml of methanol/water (1:1) and 2.9 ml of a 1N sodium hydroxide solution is stirred at 50° C. for 3 h. After the methanol has been removed in vacuo, the aqueous phase is brought to pH 2 and extracted with ethyl acetate. Customary further working up gives the title compound as a white solid: Rf (hexane/ethyl acetate/glacial acetic acid (75:25:1))=0.23.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05719141 |
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| Source dataset | uspto-grants-1998_02 |
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| ORD ID | ord-9c4213d9f7e2473fb550065d7916dcb8 |
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| Source note | uspto-grants-1998_02 |
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