HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methoxymethyl-triphenylphosphonium chloride → N-benzyloxycarbonyl-3(R,S)-(1-methoxyethen-2-yl)-1,2,3,4-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methoxymethyl-triphenylphosphonium chloride | HCID 2723798 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | N-benzyloxycarbonyl-3(R,S)-formyl-1,2,3,4-tetrahydroquinoline | HCID 19697710 | — |
| Reactant | 5(S)-tert-butoxycarbonylamino-4(S)-hydroxy-2(R),7,7-trimethyl-8-[3(R,S)-allyloxymethyl-1,2,3,4-tetrahydroquinolin-1-ylcarbonyl]-octanoic acid (N-butyl)amide | HCID 131720529 | — |
| Product | N-benzyloxycarbonyl-3(R,S)-(1-methoxyethen-2-yl)-1,2,3,4-tetrahydroquinoline | HCID 57219624 | — |
Reaction Steps
The title compound is prepared in a manner analogous to that described in Example 137b) starting from 4.8 g of N-benzyloxycarbonyl-3(R,S)-formyl-1,2,3,4-tetrahydroquinoline, 7.2 g of methoxymethyl-triphenylphosphonium chloride and 5.4 g of sodium-bis(trimethylsilyl)amide: Rf (A)=0.67.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05719141 |
| Source dataset | uspto-grants-1998_02 |
| ORD ID | ord-2602d2bcabd84ae2bd16b3016c1536b5 |
| Source note | uspto-grants-1998_02 |