反应详情

starting from 505 mg of 2(R)-benzyl-9-benzyloxy-5(S)-tert-butoxycarbonyl-amino-4(S)-hydroxy-7,7-dimethyl-nonanoic acid (N-methyl)amide via 3-[N-tert-butoxycarbonyl-4(S)-(4-benzyloxy-2,2-dimethylbutyloxy-2,2-dimethyl-1,3-oxazolidin-5(S)-yl]-2(R)-benzyl-propionic acid (N-methyl)amide (Rf (A)=0.43; FAB-MS:(M+H)+ =567) and 3-[N-tert-butoxycarbonyl-4(S)-(2,2-dimethyl-4-hydroxybutyloxy-2,2-dimethyl-1,3-oxazolidin-5(S)-yl]-2(R)-benzylpropionic acid (N-methyl)amide (Rf (B)=0.14; FAB-MS:(M+H)+ =477) in a manner analogous to that described in Examples 74a,74b and 74c), as the pure diastereomer: Rf (L)=0.17; FAB-MS:(M+H)+ =491.