Ethanol → HCID 54302995, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(4-chloro-3-fluoro-2-methylsulphenylphenyl)-3-cyclopropyl-2-(dimethylaminomethylene)-propan-1,3-dione (3 g) and O-ethylhydroxylaminehydrochloride (1 g) in ethanol (20 ml) was stirred at 25° C. for 2 hours. The mixture was poured into water and extracted with dichloromethane. The solution was dried (anhydrous sodium sulphate) and filtered. The filtrate was evaporated and the mixture purified by column chromatography on silica, using a mixture of ethyl acetate and hexane as eluent. The resulting solution was evaporated and 1-(4-chloro-3-fluoro-2-methylsulphenylphenyl)-3-cyclopropyl-2-(ethoxyiminomethyl)-propan-1,3-dione (compound 5) was obtained as a reddish gum (2.4 -g), NMR (CDCl3) δ 1.1-1.4(m, 7H), 2.7(m, 1H), 2.4(s, 3H), 3.9(m, 2H), 7.0(m, 1H), 7.3(m, 1H), 7.6(s, 1H), 17.4(s, 1H) ppm.

Provenance & Evidence