m-Chloroperbenzoic acid → HCID 53765258, compound

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A mixture of 1-[4-bromo-2-(methylsulphinylmethyl)phenyl]-3-cyclopropyl-2-(ethoxyiminomethyl)propan-1,3-dione (350 mg) and m-chloroperbenzoic acid (50-60%, 400 mg) in dichloromethane was stirred at room temperature for one hour. 1M sodium metabisulphite was added and the mixture cooled to 0° C. and filtered. The filtrate was diluted with ether, washed with 25% sodium acetate and brine, dried (anhydrous sodium sulphate) and evaporated. The residue was purified by column chromatography on silica gel, eluting with acetone and hexane, giving as a brown gum 1-[4-bromo-2-(methylsulphonylmethyl)phenyl]-3-cyclopropyl-2-(ethoxyiminomethyl)propan-1,3-dione (compound 9, 10 mg), NMR (CDCl3) δ 1.0-1.2(7H, m), 2.45(1H, m), 2.8(3H, s), 4.05(2H, q), 4.6(2H, q), 7.5-7.6(2H, m), 7.65-7.7(2H, m)

Provenance & Evidence