Hydrochloric Acid → HCID 10801994, compound

Participants

Reaction Steps

To a stirred solution of N-benzyl-N-methyl-4-nitrophenylacetamide (step (b), 24.9 g, 87.6 mmol) in tetrahydrofuran (270 ml) under nitrogen, was added dropwise 1.0M borane-tetrahydrofuran (245 ml, 245 mmol). The reaction was heated at reflux for 2 hours, cooled, then methanol (53 ml) was added dropwise followed by the cautious addition of aqueous 2.5N hydrochloric acid (100 ml). The resulting mixture was refluxed for 1 hour and then concentrated on a rotary evaporator to remove the organic solvents. Water was added to the residue and the mixture was basified to pH 11 with 2.5N aqueous sodium hydroxide. The product was then extracted into three portions of methylene chloride. The combined extracts were washed with water, dried over magnesium sulfate, filtered and concentrated to yield 23.7 g (100%) of N-benzyl-N-methyl[2-(4-nitrophenyl)ethyl]amine. The hydrochloride salt, prepared in methanol and recrystallized from 95% ethanol-ether, melted at 222°-4° C. (dec).

Provenance & Evidence