Sodium Hydroxide → HCID 19696466, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-(2-(benzylmethylamino)ethyl)phenyl)-1-benzoyl-2-thiourea (step (e), 2.4 g, 5.95 mmol) and 2.5N aqueous sodium hydroxide (20 ml) was heated at 90° C. for 35 minutes with stirring. The warm reaction mixture was then poured into water (60 ml) with stirring. The product was extracted into three portions of methylene chloride. The combined extracts were washed with water, dried over magnesium sulfate and concentrated to dryness to yield 1.71 g of crude 1-(4-(2-((phenylmethyl)(methyl)amino)ethyl)phenyl)-2-thiourea. The product was crystallized from benzene, m.p. 119°-21.5° C.

Provenance & Evidence