HCID 19696461, compound → HCID 19696462, compound

Participants

Reaction Steps

To a solution of the product of step (b) (3.89 g, 10.05 mmol) in ethyl acetate (100 ml) was added 5% Pd/C. The mixture was hydrogenated at 50 psig for 1.4 hours, until the theoretical amount of hydrogen was taken up. The catalyst was filtered and the filtrate concentrated to an oil. This was purified by chromatography (silica gel, methylene chloride: n-hexane (1:1)) to yield 2.33 g of pure N-(3-chlorobenzyl)-N-(2-(4-aminophenyl)ethyl)trifluoroacetamide as a thick oil.

Provenance & Evidence