Acetic Anhydride → HCID 53643751, compound

Participants

Reaction Steps

A mixture of N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-acetamide (3 g, 15 mmol), acetic anhydride (2 g, 200 mmol) in pyridine (50 mL) was stirred at room temperature for 18 h. Solvent was removed by rotoevaporation and the residue was purified by column chromatography on silica gel (1:1 ethyl acetate:hexane as eluant) to give the product (2.2 g) as a tan solid in 59% yield.

Provenance & Evidence