Nitric Acid → HCID 19696166, compound

Participants

Reaction Conditions

Reaction Steps

N-(5-Bromo-2,3-dioxo-2,3,4,7,8,9-hexahydro-1H-cyclopenta[f]quinoxalin-8-yl)-acetamide (0.24 g, 0.7 mmol) was dissolved in trifluoroacetic acid (10 mL), cooled in an ice bath to 0° C., and then treated with fuming nitric acid (0.5 mL) and stirred for 4 h at 0° C. After removing the solvent by rotoevaporation, the syrupy residue was triturated with water and the resulting solid was collected by filtration, washed with water and then ether and dried in vacuo (0.22 g, 81% yield). Anal. calc'd for C13H11BrN4O5.H2O: C, 38.92; H, 3.27; N, 13.94. Found: C, 38.60; H, 3.00; N, 13.66.

Provenance & Evidence