1,5-Dibromopentane → HCID 19696217, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,5-diamino-6-bromo-4-nitroindane hydrochloride (1.5 g, 5 mmol), 1,5-dibromopentane (1.4 g, 6 mmol) and diisopropylethylamine (1.3 g, 10 mmol) in DMF (100 mL) was heated at 50° C. for 24 h. The solvent was evaporated and the residue taken up in methylene chloride:water. The aqueous layer was basified with 2N NaOH and back extracted. The combined organic layers were dried over sodium sulfate, filtered and evaporated to give a syrup. The purified product (0.8 g) was obtained from column chromatography (4:1 EtOAc:methanol).

Provenance & Evidence