Hydrochloric Acid → 4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione hydrochloride

Participants

Reaction Steps

A solution of 1.25 g (2.32 mmol) of 3-[8(R or S)-[1(R or S)-tertbutoxyformamidoethyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione (diastereomer A) in 10 ml of ethyl acetate was treated with 30 ml of a saturated solution of hydrogen chloride in ethyl acetate and stirred at room temperature for 18 hours. The solid obtained was removed by filtration and dried to give 1.0 g of 3-[8(R or S)-[1(R or S)-aminoethyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione hydrochloride (diastereomer A) as a red solid of melting point 324°-325° C.

Provenance & Evidence