HCID 14570994, compound → HCID 14570995, compound

HRID 863574Notes

Reaction equation

[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]([CH:11]=[O:12])[CH:3]=1.C(Cl)Cl.[CH3:16][CH2:17][O:18]C(C)=O>>[O:12]1[CH2:16][CH2:17][O:18][CH:11]1[C:4]1[CH:3]=[C:2]([CH3:1])[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=1

Participants

Reactant 2

HCID 14570994HCID 14570994, compound

HCID 21226138Dichloromethane ethylacetate

Product 1

HCID 14570995HCID 14570995, compound

Procedure

2-(1,3-Dioxolanyl)-4-methyl-5-nitropyridine was synthesized by the method of Example XLIX except that the starting material was 4-methyl-5-nitropyridine-2-carboxaldehyde. Yield: 2.3 g (91%); mp 77°-79° C.; (lit mp 77° C.); TLC, Rf 0.74 (CH2Cl2 /EtOAc, 3:2, v/v); 1H NMR (90 MHz, CDCl3) δ 2.65 (s, 3H, 4-CH3), 4.10 (s, 4H, CH2CH2), 5.85 (s, 1H, 2-CH), 7.50 (s, 1H, 3-H), 9.12 (s, 1H, 6-H). Anal. (C9 H10N2O4) C, H, N.

Sources & evidence

ORD record: ord-64cf6954329a45ae8869af1631233d45
Source dataset: uspto-grants-1998_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05721259

Reaction notes

Loading…